Paper on cardiac hypertrophy published by Umeå University
Cardiac hypertrophy and decreased high-density lipoprotein cholesterol in Lrig3-deficient mice. This interesting paper was financially supported by CarTarDis and published by partner Umeå University in Am J Physiol Regul Integr Comp Physiol (March 23, 2016).
Genetic factors confer risk for cardiovascular disease. Recently, large genome-wide population studies have shown associations between genomic loci close to LRIG3 and heart failure and plasma high-density lipoprotein (HDL) cholesterol level. The published paper reports that report that Lrig3-deficient female mice developed signs of cardiac hypertrophy, and Lrig3-deficient mice also showed reduced plasma HDL-cholesterol and free glycerol levels at 12 months of age. These findings in mice complement the human epidemiological studies and suggest that Lrig3 may influence heart function and plasma lipid levels in mice and humans.
The paper can be downloaded from PubMed. http://www.ncbi.nlm.nih.gov/pubmed/?term=27009049