Heart@Target, joint meeting of three FP7 consortia on Cardiovascular research.
Three consortia of EU FP7 projects which are focused on identification and validation of new targets for drugs in cardiovascular disease organized a joint meeting in Zandvoort, The Netherlands on Tuesday the 27th and Wednesday 28th of September 2016. With 60 participants from the three consortia, represented by researchers from academia, several SME’s and big pharma from 15 European countries, the attendance exceeded our expectations. The joint meeting resulted in informal interactions, discussions and new collaborative initiatives. This open sharing of technologies and latest research results leads to optimal dissemination of latest developments supported by the EU and thus aids the increase of output from these research projects in a very relevant disease area.
The meeting started on Tuesday afternoon with a session opened by the project officer of the CarTarDis project officer, Dr. Grzegorz Owsianik. Dr. Owsianik stressed that CVD is still the main cause of death in Europe and therefore a very important research area supported by the EU in FP7 projects but also several projects under the H2020 funding. Demonstration of this support are the three project consortia that were presented by their coordinators and he called this joint meeting an excellent and unique initiative in which the important issue of knowledge sharing in R&D is shown in optima forma.
The CarTarDis consortium, introduced by the coordinator, prof. Dr. A. van Gool (TNO) aims to identify and clinically validate targets that are suitable to start pharmaceutical drug screening and further development. The coordinator of the CVgenes@target consortium, prof. Dr. H. Schunkert (German Heart Centre Munich) explained that this project aims the exploitation of genomic variants affecting coronary artery disease and stroke risk for therapeutic intervention, while the Transcard consortium, presented by coordinator prof. Dr. J.A. van Kuivenhoven (UMCG) aims for translating disease into cardiovascular health by identifying new targets for pharmaceutical intervention.
Highlights from the consortia
Dr. N. Samani from the University of Leicester, UK, representing CVgenes@target informed the audience on the latest developments in the translation of genetic discovery into mechanisms and development of novel therapies. Dr. P. Gibbon from Fraunhofer Institute, Germany showed the added value of phenotypic screening in target validation strategies and in compound repurposing. Prof. dr. A. Tybjærg Hansen from Rigshospitalet in Copenhagen in Denmark and representing The Transcard project showed how very valuable information can be extracted and different hypotheses on targets can be validated in large human populations. One example is the Copenhagen cohort in which thousands of individuals are followed for an average of 24 years, collecting genetic data, clinical data and incidence of cardiovascular events. Second highlight from the Transcard project was presented by Dr. A. von Eckardstein, University of Zurich. He showed new technology development in high-throughput microscopy and high-content screening using optimized in-vitro assays. Dr. E. Hurt-Camejo, AZ, Stockholm, Sweden from the CarTarDis consortium is a representative of big pharma industry and gave the audience a comprehensive overview of pharma workflows in target discovery. She explained that the high attrition rates for new drugs, that pharma industry has been confronted with in the past few years, despite high investments in discovery can partially be explained by the fact that the new targets were often not causally linked to the disease and often the genetic evidence was very weak. These observations were now incorporated into the AZ target discovery workflow which was also adopted by the CarTarDis consortium. Dr. K. Holmstrøm from Bioneer, Copenhagen presented the multimodal molecular imaging capabilities of the CarTarDis consortium, which are quite unique as they are comprised of several state of the art technologies, such as mass spectrometry imaging, in-situ-hybridisation for mRNA detection and classical IHC stainings. These imaging techniques were used to visualize the expression of the CarTarDis selected targets in biobanked CVD tissues.
In addition to the goals and highlights from the consortia, the second day was a networking event with pitches of the available technologies presented by the academia and SME’s. The three FP7 consortia seek further collaboration and aim to efficiently use the resources and expertise represented within the consortia.
Links to the websites of TransCard and CVgenes@target.